Cedars-Sinai Medical Center

Date of Award

09.24.2018

Program

Crohn's Disease, Therapeutics

Amount

$1,906,532

Term of Grant

48 months

Project Title

The Diagnostic and Therapeutic Potential of Targeting Microorganisms in Creeping Fat to Treat Ileal Fibrosis in Crohn's Disease

Project Description

Creeping fat is a poorly studied phenomenon that only occurs in Crohn’s disease and is thought to contribute to intestinal fibrosis and stricturing. This grant aims to explore the role of the microbes in the creeping fat and understand how they contribute to the intestinal inflammation and fibrosis seen during Crohn’s disease.