The Cleveland Clinic Foundation

Date of Award



Crohn's Disease, Prevention



Term of Grant

23 months

Project Title

Biomarker of innate immunity perturbation sub-classifies Crohn's disease

Project Description

This project proposes to establish the biological and clinical relevance of abnormal Paneth cell phenotype (PCP) and immune perturbation as putative factors responsible for the causes, pathology and rise in the incidence of Crohn’s disease in a population-wide setting of rural versus urban China.