Regents of The University of Michigan

Date of Award

11.19.2025

Program

Therapeutics

Amount

$2,498,429.00

Term of Grant

36 months

Project Title

The SYMPTOM Trials: Scalable, community-based methods for persistent IBS-like symptoms in Crohn's Disease in remission.

Project Description

This randomized, placebo-controlled clinical trial aims to demonstrate the safety and efficacy of tricyclic antidepressants (TCAs) for Crohn's disease patients who have persistent gastrointestinal symptoms despite controlled inflammation. Results from this study will inform the incorporation of TCAs into clinical practice to improve patient quality of life.