Trustees Of The University Of Pennsylvania

Date of Award






Term of Grant

36 months

Project Title

The Ultra Processed Western Diet, the Gut Microbiome, and Dietary Xenobiotic Exposure in Crohn's Disease

Project Description

There is a need to develop a mechanistic understanding of how dietary therapies such as EEN are efficacious in the treatment of CD. This proposed study will investigate the regulation of beta-glucuronidases in the human gut microbiome by EEN, providing evidence for a previously unrecognized mechanism by which food chemistry may play a role in CD.