Trustees Of The University Of Pennsylvania

Date of Award

02.25.2021

Program

Crohn's Disease, Prevention

Amount

$1,663,309

Term of Grant

36 months

Project Title

The Ultra Processed Western Diet, the Gut Microbiome, and Dietary Xenobiotic Exposure in Crohn’s Disease

Project Description

There is a need to develop a mechanistic understanding of how dietary therapies such as EEN are efficacious in the treatment of CD. This proposed study will investigate the regulation of beta-glucuronidases in the human gut microbiome by EEN, providing evidence for a previously unrecognized mechanism by which food chemistry may play a role in CD.