Trustees Of The University Of Pennsylvania
Date of Award
02.25.2021
Program
Crohn's Disease, Prevention
Amount
$1,663,309
Term of Grant
36 months
Project Title
The Ultra Processed Western Diet, the Gut Microbiome, and Dietary Xenobiotic Exposure in Crohn’s Disease
Project Description
There is a need to develop a mechanistic understanding of how dietary therapies such as EEN are efficacious in the treatment of CD. This proposed study will investigate the regulation of beta-glucuronidases in the human gut microbiome by EEN, providing evidence for a previously unrecognized mechanism by which food chemistry may play a role in CD.