University of Texas System
Date of Award
Crohn's Disease, Therapeutics
Term of Grant
A Crohn’s Disease-on-a-Chip for Mapping the Intercellular Crosstalk in the Epithelium-Microbiome Axis
Current laboratory models for CD are limited and do not consider the multifactorial nature of the disease comprising intricate interactions between patient cells and gut resident bacteria, which are different in each CD patient. If successful, this proposal will help validate a patient-derived CD-on-a-chip model system that can be used to understand complex disease processes. This personalized approach could change the way new therapeutic avenues are explored and how CD patients are treated.