University of Texas System

Date of Award

02.26.2019

Program

Crohn's Disease, Therapeutics

Amount

$1,767,225

Term of Grant

36 months

Project Title

A Crohn’s Disease-on-a-Chip for Mapping the Intercellular Crosstalk in the Epithelium-Microbiome Axis

Project Description

Current laboratory models for CD are limited and do not consider the multifactorial nature of the disease comprising intricate interactions between patient cells and gut resident bacteria, which are different in each CD patient. If successful, this proposal will help validate a patient-derived CD-on-a-chip model system that can be used to understand complex disease processes. This personalized approach could change the way new therapeutic avenues are explored and how CD patients are treated.