University of Texas System
Date of Award
02.26.2019
Program
Crohn's Disease, Therapeutics
Amount
$1,767,225
Term of Grant
36 months
Project Title
A Crohn’s Disease-on-a-Chip for Mapping the Intercellular Crosstalk in the Epithelium-Microbiome Axis
Project Description
Current laboratory models for CD are limited and do not consider the multifactorial nature of the disease comprising intricate interactions between patient cells and gut resident bacteria, which are different in each CD patient. If successful, this proposal will help validate a patient-derived CD-on-a-chip model system that can be used to understand complex disease processes. This personalized approach could change the way new therapeutic avenues are explored and how CD patients are treated.